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Although patients with severe conditions were excluded, the absence of multivariate analysis limited adjustment for confounders

Consult a professional if: You are experiencing persistent, worsening, or concerning symptoms like extreme fatigue, unexplained weight loss, or chronic pain

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Mechanism of Action Inhibits Nicotinamide N-Methyltransferase (NNMT) Increases intracellular nicotinamide and NAD levels Improves mitochondrial efficiency and energy metabolism Supports lipolysis and fat oxidation Reduces adipocyte (fat cell) growth and proliferation Modulates inflammatory pathways and insulin signaling These effects may lead to enhanced fat metabolism, better blood sugar regulation, improved endurance, and a general increase in metabolic flexibility

However, there is no established direct causal link between vitamin B12 and joint pain in the medical literature